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I have these 2 case studies that I need help with (see the attachment)I need to get full mark
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CASE 10
A 17-year old male came into the ER with fatigue, a sore throat and a high fever. CBC
indicates relative leukocytosis and absolute neutrophilia. Swabs were sent for strep
testing, and results are pending. Nevertheless, the physician suspects a bacterial
infection based on CBC.
1. If this was indeed an extracellular bacterial infection, which MHC complex would
most likely be utilized the most to process the extracellular antigens? (1 pt)
2. If an antigen is to be processed and presented on MHC II complex, where do the
MHCII molecule and peptide (antigen) initially interact within the cell? (1 pt)
3. What does an MHC II molecule bind to initially in the endoplasmic reticulum to
prevent it from binding endogenous antigens? (1 pt)
4. Which adaptive T cell subtype will recognize antigens displayed on MHC II
molecules? Indicate one function of this lymphocyte. (2 pt)
5. What type of cells can present antigens on both MHC I and MHC II complexes?
Indicate 2 examples of these types of cells. (2 pt)
6. In theory, can antigens processed and displayed on MHC II complexes induce
antibody production of many isotypes? Please explain your answer. (2 pts)
CASE 9
A 23-year old male presented with fatigue and dark colored urine (especially in the
morning). Routine laboratory testing revealed decreased blood counts (anemia),
thrombosis, increased bilirubin and hemoglobinuria. Lastly, molecular testing revealed
a mutation in the CD55 gene.
1. What is the most likely diagnosis? (1 pt)
2. What complement regulatory protein is lacking in this patient? (1 pt)
3. What is the function of this regulator (answer from question 1)? (1 pt)
4. Which complement pathway(s) may be un-regulated in this patient? (2 pts)
5. In this patient, would you expect increased or decreased C3b levels on patient RBCs?
Please explain your answer (2 pts)
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