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LECOM School of Pharmacy
Pharmaceutics III DE 2022/2023
Drug Stability Assignment
Dr. Miroshnyk
Your name_____________________________
Consider the accelerated stability testing data for a new drug product and perform the
following:
1. Compute the missing parameters and fill out the table.
2. Use Excel to generate an Arrhenius plot (log k vs 1/T)
3. Solve the Arrhenius Eq for kapp at 25 0C (= 298 K).
4. Calculate t90 assuming that the initial drug concentration was 50 mg/tablet.
5. Assign the expiration date of this new drug product, assuming that it will be
manufactured on September 1st, 2022.
Accelerated Stability Data
Temperature
(0C)
70
80
90
Temperature (K)
Rate Constant
(k) (min-1)
1.73E-05
3.38E-05
6.45E-05
1/K
Log k
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